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Article Information, PDF download for Acyclovir in the Treatment of Recurrent Frequency and significance of epithelial atypia in laryngeal papillomatosis. Download PDF The aim of the present study was to conduct a literature review on oral papillomatosis as well as to review a clinical case. Keywords. Download PDF. More article Laryngeal papillomatosis. Oral cavity Papilomatosis laríngea. Cavidad oral. Abusos sexuales. Faringe. Laringe. Cavidad nasal.

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ESTENOSIS SUBGLOTICA EPUB Estenosis subglotica consecutiva a procedimientos de PAPILOMATOSIS LARINGEA PDF DOWNLOAD. I found one site (database) with millions of pdf ebooks, programs, music, films, etc , but I don't know if there is laringe y faringe histologia pdf. Print. Download PDF. More article options. ePub · Statistics · Vol. Issue 3. Disfonía infantil precoz como síntoma de alerta de la papilomatosis laríngea juvenil. Visits. Download PDF Juvenile laryngeal papillomatosis (JLP) is the second most common cause of dysphonia in children, after true vocal cord.

Skin ultrastructure shows vesicular lamellar bodies ghosts and a paucity of secreted lamellar granules in the stratum corneum. Ichthyosis Management of survivors is similar to management of severe CIE and includes use of emollients, keratolytics, and retinoids. Health care resources for this disease Expert centres 70 Diagnostic ictiosis congenita 20 Patient organisations 23 Orphan drug s 4. Molecular analysis, if available, reveals ABCA12 mutations. Later in life, the differential diagnosis includes congenital ichthyosiform erythroderma CIElethal restrictive dermopathy, infantile systemic hyalinosis, and Neu-Laxova syndrome see these terms. Ichthyosis ictiosis congenita ichthyosis-like disorders exist for several types of animals, including cattle, chickens, llamas, mice and dogs.

In the case of oropharyngeal carcinoma, a related tumour that we shall mention later, the existence of viral DNA expression also has to be demonstrated. This can be done indirectly by determining p16 protein, or directly by determining E6 gene mRNA expression. The different therapeutic methods are the topical application of substances such as podophyllin and trichloroacetic acid, cryotherapy with liquid nitrogen, 12,13 and surgical techniques, including CO2 laser, electrocoagulation and surgical excision.

HPV therapy has changed over recent years, 13 and now new therapeutic methods are used such as alpha interferon, 9,10 imiquimod, 5-FU and other cytokines. This virus has typically been associated with cervical cancer, but has also been shown to be an important aetiological factor in squamous cell carcinoma 1 of the oropharynx and, less commonly, the oral cavity.

Treponema pallidum Infections—T. Its main route of infection is sexual, but it can also be transmitted via the placenta.

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In recent years there has been an increased incidence of the disease, due to growing HIV infection and immunosuppression. Most cases occur in young adults. It is particularly frequently transmitted amongst homosexual males. It comprises a painless, indurated ulcer with raised edges that lasts between 3 and 6 weeks, and is highly contagious. Although it rarely presents in the pharynx, we must consider it in the presence of large necrotic ulcers, usually in the tonsillar area, with associated ipsilateral lymphadenopathies Fig.

Figure 2. Tonsillar ulcer chancre in a patient with primary syphilis. Cases have also been described of primary syphilis presenting as isolated cervical lymphadenopathies, suspected as malignant, that have been diagnosed by serological tests and subsequent histopathological study. Prompt diagnosis is essential to prevent spread of the disease. Syphilis can be diagnosed either directly or indirectly. In the first case, T. Identifying the micro-organism ensures a diagnosis, but a negative result does not rule out the disease.


Samples of the lesion from the anus or mouth are not valid for direct observation under the microscope because there are other species of saprophytic spirochaete in these areas. There are two types of tests, reaginic or treponomal. In addition, sexual contact must be avoided during treatment.

Intramuscular penicillin G benzathine is the treatment for primary and secondary syphilis, 2. Doxycycline or tetracycline can be used in the case of allergy.

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Therefore the presence of a pharyngeal lymphogranuloma venereum can act as a reservoir for infection amongst MSM. The benchmark technique for diagnosing C. However, it is recommended that other techniques be used to confirm a positive result, particularly molecular testing, 31 which includes hybridisation and nucleic acid amplification reactions, PCR being the most frequently used test currently.

Erythromycin or ofloxacin for 7 days can be used as alternatives. Neisseria gonorrheae Infection N. It usually presents as pharyngitis, but can appear as tonsillitis, 34—39 gingivitis, stomatitis or glossitis. A small group of cases has also been described where the transmission route appears to be autoinnoculation via genital infection.

Gram staining of a sample from the lesions is an excellent method for rapid diagnosis gram-negative intracellular diplococci , but should be confirmed by one of the other methods, principally cell culture in Neisseria-selective media, but PCR can also be used. Infection by the Herpes Simplex Virus There are two types of herpes simplex virus HSV , type 1 and type 2, and the sexual transmission route is key for both. HSV-1 causes lesions in the oral cavity essentially, primary infection generally occurs in childhood through mucocutaneous contact with an infected person.

By contrast, the principal transmission route of HSV-2 is sexual, usually in young people, most commonly causing genital lesions, although cases of oral ulcers caused by HSV-2 are also seen. The sexual route is most common amongst young adults. The clinical picture is fever, sore throat and painful blisters on the oral and gingival mucosa.

In the more severe cases, gingivostomatitis can be accompanied by dysphagia and lympadenopathies, and in some cases, such as in adolescents, serious pharyngitis can present. This stage of the disease usually resolves spontaneously in 10—14 days in immunocompetent patients.

Once resolved, the virus remains latent in the lymph nodes, and therefore can reactivate and cause recurrent infections, this occurs more frequently with HSV-1 than HSV There are at least two cycles for viral replication: a lytic infection and b lysogenic infection.

In cases of lytic infection, the virus arrives into the para-basal cells with replication ability, it penetrates the cytoplasm and later the nucleus. Once within the nucleus, it replicates in the episomal area, without integrating into the cellular genome, producing thus approximately 20 viral copies. These complete viral particles cause cell death and remain thus free and in proximity to epithelial surfaces. In cases of lysogenic infection cell genome is directly affected.

This is the case of the high risk HPV 16 and After reaching cell nucleus, the virus integrates into the host's cell genome, mainly segments E6 and E7. In this case, virus replication assumes a latency stage until the host cell replicates its own DNA as well as DNA of integrated viruses.

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Viral DNA segments are transcriptionally active after cell division; this guarantees their propagation 13 Unlike lytic infection cases, this type of infection is observed in cells experiencing malignant growth. These proteins are able to form compounds with cellular gene products which regulate cellular cycle, among which p53 and Rb can be found. Oncoprotein E6 creates a compound with p53 protein, whereas E7 creates a compound with Rb protein. Rb protein regulates the passage from G1 to S Oncoprotein E7 sequesters Rb preventing it from regulating cell proliferation proteins, this forces the cellular cycle to remain in synthesis phase.

Progressive changes experienced by keratocytes modify the microenvironment and alter the epithelium's balance though cellular proliferation stimuli guided by secretion of alpha and beta epidermal growth factors. L1 and L2 assemble the virus and place themselves in mature squamous cells to later slough off over 1, copies per cell. In benign lesions, such as tongue papilloma, proliferation of episomal DNA particles promotes abnormal epithelium growth, increasing thus gene errors of the cells gastogenesis.

E6 and E7 promote virus proliferation and immortalization. This mechanism is mainly induced by loss of DNA telomeres, which inhibits apoptosis, increases number of infected cells and decreases p53 and Rb acetylation and phosphorylation.

Moreover, angiogenic factors expression is promoted.

Such is the case of the vascular growth factor which disorganizes cell cytoskeleton and extracellular matrix affecting regulation factors which take part of the health of these structures.

For instance, peri-nuclear vacuoles formation is observed, enlarged, irregular and hyperchromatic nuclei as well as bi-nucleation. Condyloma is the most common morphologic manifestation of HPV infection condyloma acuminatum. She did not work outside her house, was born and residing in the Estado de Mexico State of Mexico. Her blood type was O, Rh positive. As part of her family history she reported her father as carrying multiple sclerosis and a sister afflicted with rheumatoid arthritis.

The patient denied any drug addiction. She was afflicted with multiple juvenile breast fibroadenoma in the left breast, which were surgically treated. Sexual activity began at She reported one sexually active partner, denied practice of oral-genital sex.

She experienced pregnancy and was delivered of a 3. One year before she had been subjected to cytology and colposcopy studies in the lower genital tract, in addition to breast check-up. Results proved negative for cancer and HPV. Family planning method used by the patient was intrauterine device. The patient sought consultation for the first time in April , complaining of ventral glossodynia with a three month evolution.

After this, she experienced a feeling of foreign body and bulging in the soft tissue, with progressive centrifuge growth until formation of a lentil-shaped tumor which bled when contacting the hard palate and during mastication. She attended a doctor's office where she received non-specified systemic treatment which did not elicit satisfactory results.

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The mouth was inspected through a colposcopy procedure with 0. Said procedure revealed a lesion of approximately 1cm diameter, of a pinkish hue, circular shape, with jagged edges, without pedicle and of an avascular nature Figure 1. Once the study was completed, the patient was informed about diagnosis and desirable treatment.

Figure 1.

Direct inspection of the mouth under colposcopic perspective. I Hinselmann, , with 0.