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In addition, the amino acid substitution at position in E2 protein is a clade-specific adaptive mutation that allowed the differentiation of the B2 serine and B3 phenylalanine clades. A recent study demonstrated that the mutation of E2-LQ was beneficial for the dissemination of the virus in Aedes albopictus Whether the naturally occurred amino acid substitution of E would have beneficial effect on the viral fitness in Aedes aegpti, the mosquito vector in the Philippines and Caribbean region, warrants further investigation.
Traceable microevolution of the viral genome gives rise to the probable transmission route of virus Whereas, the amino acid substitution of Glutamine to Arginine at E3 position 19 was concomitant with the nsPN and was observed in all virus isolates from the Philippines except isolates collected from Compostela Valley and Aurora. Besides, an additional amino acid substitution of Proline to Leucine at E1 position was observed in all ER-bearing strains and the two China JC and China-sy strains collected in Whether this substitution happened convergently in Malaysia and the Philippines remained inconclusive.
Unlike the CHIKV epidemic involving the Asian genotype during the to , the risk of widespread outbreak remains transitory as the human-Aedes aegypti interaction still lacks outbreak sustainability potential at a local scale, therefore requiring continuous virus importation Although the B3 clade appeared as early as , high magnitude and rapid dissemination of the virus was only observed during the CHIKV outbreaks in the Philippines acquisition of nsPN and later during its nationwide and global spread acquisition of EL and ER.
Out of the three unique adaptive amino acid substitution, two nsP and E were predicted as positively selected sites.
Currently, it is still unclear if these amino acid substitutions at nsP, E and E are products of CHIKV adaptation to the Aedes aegypti in local transmission setting. Sequential acquisition of mutations that could have provided beneficial effect to the viral fitness has been previously demonstrated Whether, the amino acid substitution of E exerts the same effect, remains to be investigated. It is possible that these mutations confer the newly emerging CHIKV with the ability to sustain epidemic human-Aedes aegypti transmission cycle.
Unique amino acid substitutions observed among the CACV suggests multiple independent virus dissemination events contributing to the global spread.
While the possible biological importance of these mutations are still unknown, the genetic signatures identified in the study represent interesting candidates for future in-depth study and epidemiological follow-up.
Sequencing of additional isolates from the outbreak regions and local reservoirs would allow better delineation of the evolution pattern of this globally emerging Asian CHIKV.
These serum samples were collected in from different provinces in the Philippines that represent the circulating viral strains during the outbreaks in the country. Sample preparation, genome sequencing and assembly All laboratory activities involving the virus isolates was conducted following BSL-2 biosafety practices and procedures in BSL-2 laboratory.
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