PDF | A rapidly increasing selection of laboratory equipment can be fabricated with open-source three-dimensional printers at low cost. lab-on-a-chip architectures, where ﬂ ow paths. are created layer by layer, but are adaptable to. a much. Open-Source Lab: How to Build Your Own Hardware and Reduce Research Costs. Joshua Pearce. Loading Preview. Sorry, preview is currently unavailable. The Open-Source Lab: How to Build Your Own Hardware and Reduce Research Costs by . Print/export. Create a book · Download as PDF · Printable version.
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Open-source lab: how to build your own hardware and reduce research costs . If history has favored open source, why are we entering a new movement of. Open-Source Lab: How to Build Your Own Hardware and Reduce Scientific Research Costs details the development of the free and open-source hardware. His new book, published by Elsevier, is a step-by- step DIY guide for making lab equipment. The essential tools are a 3D printer, open-source.
Nature volume , page 30 January Download Citation Subjects Technology Sally Tinkle and others see Nature , —; highlight the importance of open-source software and data sharing in materials science. But researchers should also be developing free and open-source hardware to radically reduce the costs of their experimental work. Harnessing open-source methodology will ensure that funding used to develop scientific equipment is spent only once. A return on investment is achieved through digital replication of devices for just the cost of the materials required. Pearce Open-Source Lab, Elsevier;
His research concentrates on the use of open source appropriate technology to find collaborative solutions to problems in sustainability and poverty reduction. His research spans areas of electronic device physics and materials engineering of solar photovoltaic cells, and RepRap 3-D printing, but also includes applied sustainability and energy policy. He has published more than peer-reviewed articles and is the author of the Open-Source Lab: Open-Source Lab.
It will guide the inexperienced reader making him comfortable to embrace this technological and social advances in a very practical way, resulting in very significant cost reductions for researchers and teachers. Joshua Pearce details how the manufacturing revolution, which puts 3-D printing, open-source microcontrollers and free software into the hands of the people, enables makers to develop "powerful research tools at unprecedented low costs.
The topics he covers include software rights, best practices and etiquette for using open-source hardware, open-source microcontrollers, open-source centrifuges and spectrometers, colorimeters, and even open-source laser welding.
There are also some helpful hints for those who are 3D-printing their equipment for the first time. Pearce has put into Open-Source Lab. Additionally Dr. I documented both our work and dozens of examples from the community in a book: Open-source Lab, which should be published next month.
The idea of open-sourcing scientific equipment is catching on and it is really exciting to see what is going on with groups all over the world like at Tekla Labs.
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Thanks in advance for your time. Skip to content. Search for books, journals or webpages All Webpages Books Journals. View on ScienceDirect. The structure editor is the essential part for the definition of molecules within the ELN as it generates the connection table.
With the database molecule table indexed over the InChIKey values, a new molecule entry is created if the unique identifier is not found. In that case, generic information is generated by OpenBabel and complemented by querying the PubChem database.
The molecular structure of the molecule in combination with the assigned information then serves as a substantial part for the creation of samples, which are the physical equivalent to the designed molecules. Only samples can be assigned to research actions and reaction plans.
The DB structure of the sample allows adding more information to a given theoretical molecular structure and includes the properties that depend on a specific experimental case such as the purity.
The registration and consequent use of either molecules or samples while working with the Chemotion ELN is the basis for a well-organized and in the end, reproducible synthetic documentation. The association of samples to molecules allows the cumulation of information while offering flexibility in the definition of single samples and their visualization.
As an example, MDL molfiles are stored both for the sample and its associated generic molecule giving the opportunity to individually style samples created from the same molecule.
A very similar procedure is established for the assignment of CAS registry numbers of which all available ones are stored with the molecule allowing the user to select and store one of them with a particular sample a detailed description of the process is given in the Additional file 1. While such a clear differentiation between molecules and samples is not reflected in most of the other chemistry ELNs, this is a central point in the development of the Chemotion ELN. The representation of a physically used substance or its preparation in the ELN includes the summary of the available data from the related molecule allowing a fast availability of all information that is necessary for a fast management of the research projects.
The automatically provided data, as well as the input given by the user, are organized in three main tabbed panels which consist of 1.
Right: view of the analysis tab of the given sample 2. Other panels can be added through the ELN customization with plugins that provided the user extended functions: request to SciFinder and a direct connection to the search results.
The embedding of SciFinder functions tab 4 requires the configuration of an ELN plugin which is also available on a public repository. However, the institution dependent credentials for the SciFinder service need to be configured on the server.
This step automatically generates an access token with a day validity. The hit count of the search results is retrieved with a link to the answer set directing to the SciFinder web application. The history of the latest requests and answers of the current user is also listed. As soon as a molecule search in SciFinder is processed, the results are also given in the list of molecules, indicating the search date, whether the structure is registered in SciFinder or not and the number of results.
The direct visibility of published structures via the ELN allows a fast access to information which was, up to know, only to be retrieved via the SciFinder page directly. As given for the embedded SciFinder feature, the matching molecules are accessible via a direct link to the PubChem Index of the identified item.
The information on the presence of the requested structure in the NCBI database is summarized in the molecule and sample lists Fig. While being less flexible according to customized search strategies, this limitation allows the automated processing of the requests instantly with the creation of a new molecular structure.
A reaction is created easily by the addition of information to a reaction template Fig. The user can assign samples and molecules to the reaction in their distinct function as starting material, reagent or product. The implemented dependencies between the given information and the molecular weights allow the calculation of all necessary values as long as the basic information is given.
The structure of the reaction user interface is very flexible enabling the exchange of elements at any time per drag and drop. Samples that have been assigned to a role as starting material can be changed into reagents during the planning of the reaction. The assignment of samples to particular roles within a reaction act upon the calculations, as the equivalents are always calculated with respect to the given amount of starting material which is set to 1 per default.
When several starting materials are entered, either one of them, or a reactant, has to be set by the user as the reference material with 1. A unique feature of the Chemotion ELN is the record of real values in parallel to the data of the originally planned experiments. This allows the accurate documentation of the real experiment while having the possibility to use the planned procedure as a template that can serve as a copy for a repeat in a standard way.
The change from target to real values is implemented via a switch from value T to R for each sample. The chemicals that are assigned to the reaction are accessible via a direct link to the detailed level of the sample list.
All data and changes that are submitted to the samples like the density of a chemical are considered instantly for the calculation of the reaction. The ELN is designed on the one hand to offer as much flexibility as possible but on the other hand to limit user actions that could compromise the integrity of the experimental data. While all parameters of a reaction can be inputted and submitted either via the predefined or free text fields within the information panels like under the Scheme tab, there are other fields where calculated data are only visible but not editable.
An example for the latter limitation is the yield field displayed for reactions. Journal of Micromechanics and Microengineering, 27 3. Application of 3D printing to prototype and develop novel plant tissue culture systems. Plant Methods, 13 1 , p. Springer, Cham. Sensors, 17 4 , p.
PloS one, 11 10 , p. International Society for Optics and Photonics. Design and construction of an automated OSL reader with open source software and hardware. Radiation Measurements.
ACS Combinatorial Science. Environmental monitoring system based on an Open Source Platform and the Internet of Things for a building energy retrofit. Automation in Construction, 87, pp. Philip J. Zalesskiy, Ralph C.
Sigerson, Jennifer S. Mathieson, Leroy Cronin. Digitization of multistep organic synthesis in reactionware for on-demand pharmaceuticals. Science 19 Jan Vol.
DOI: Single-cell RNA-seq of rheumatoid arthritis synovial tissue using low-cost microfluidic instrumentation.