Dermatitis herpetiformis was first described by Louis. Adolphus .. Sanjinés L, Martínez M, Magliano J. Dermatitis herpetiforme como carta de. Keywords: Celiac disease, Dapsone, Dermatitis herpetiformis, Diet, gluten-free, Transglutaminases Dermatite herpetiforme e dermatose por IgA Linear; pp. La dermatitis herpetiforme constituye una enfermedad crónica, hereditaria, de base inmune, que afecta preferentemente a la población del norte de Europa.
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La dermatitis herpetiforme constituye una enfermedad crónica, hereditaria, de base inmune, que afecta El Texto completo solo está disponible en PDF. Download PDF La dermatitis herpetiforme es una enfermedad ampollosa autoinmune que aparece como expresión cutánea de la intolerancia al gluten. text new page (beta); English (pdf) · Article in xml format; How to cite this article; SciELO Dermatitis herpetiformis (DH) or Duhring-Brocq disease is a chronic bullous Dermatite herpetiforme é uma doença bolhosa crônica caracterizada por.
Palabras clave: dermatitis herpetiforme intolerancia al gluten Dermatitis herpetiforme is a chronic, hereditary disease having an immune basis. It preferentially affects the Northern Europe population. Its approximate frequency is one case per every ten thousand persons and it predominates in males with a 1. At present, it is considered to be a manifestation form of celiac disease CD , the participation of gluten being clearly demonstrated in its development. Clinically, it is characterized by vesicle-bullous type skin lesions, accompanied by intense itching.
It is likely that some cases initially described were of bullous pemphigoid or linear IgA dermatosis bullosa, given the unavailability of better diagnostic tools at that period. In Civatte demonstrated that, in pemphigus, the formation of blisters was intraepidermal, differently from bullous pemphigoid and DH, which present subepidermal alterations.
In Van der Meer, in turn, revealed the occurrence of granular IgA deposits in those same locations, which constituted a major milestone for the understanding of this disease and permitted for the first time its differentiation from linear IgA dermatosis bullosa. Studies conducted in Scotland and Sweden found an incidence of It affects predominantly Caucasians compared to African-Americans or Asians.
In the latter, besides being rare, the disease is characterized by often not being associated with CD, besides the prevalence of fibrillar IgA deposits on direct immunofluorescence, and a different HLA pattern. On gender incidence, males predominate in a ratio of compared to females, but in younger individuals this ratio is reversed, with affected females being more prevalent. Hervonen evaluated 6 pairs of twins, and noted that 3 pairs had DH, and in 2 pairs one twin had DH and the other had CD, and also in just a pair, one twin had DH and the other none of the diseases.
Despite the probable similar genetic origin, environmental factors may influence the occurrence of either pathology. DH and CD are significant examples of pathologies in which environmental factors participate in the physiopathogeny. Dieterich et al first described them in , suggesting that this was the primary autoantigen recognized by IgA in CD and DH.
TTG is widely distributed in the human body, and is considered a surrogate marker for CD diagnosis.
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