The overall objective of this study was to develop an oral sustained release metformin hydrochloride tablet by using hydrophilic Eudragit RSPO alone or its. One of the polymers of this type with broad applications is the Eudragit® RS or poly(ethyl acrylate-co-methyl methacrylate-co-trimethylammonioethyl. (Italian Edition) PDF DJVU by Vivek S Dave Vivek S Dave. The deformation behavior of Eudragit RTM RS PO, Eudragit RTM RL PO and their.
|Language:||English, Spanish, Arabic|
|ePub File Size:||16.87 MB|
|PDF File Size:||8.32 MB|
|Distribution:||Free* [*Register to download]|
1 g of the substances dissolves in 7 g aqueous ronaldweinland.infos on recent literature regarding use of Eudragit polymer in different. made up of Eudragit RSPO and Eudragit RLPO in. With Eudragit L in different proportions on drug release kinetics was studied. Eudragit: a versatile polymer excipient - Download as Powerpoint Presentation . ppt /.pptx), PDF File .pdf), Text File .txt) or view In Vitro Release Kinetic Study of Theophylline From Eudragit RS PO and Eudragit RL PO Matrix Tablets. PDF | Sustained Release Drug Delivery System (SRDDS) is designed to release a Download full-text PDF .. HPMC KM Eudragit RLPO, Eudragit RSPO.
Recent advances in gastro retentive drug delivery systems and its application on treatment of H. Pylori infections. J Anal Pharm Res. DOI: To overcome this restriction and to increase the bioavailability of these drugs, controlled drug delivery systems with a prolonged residence time in the stomach can be used. Gastric retention drug delivery system can be used to prolonged residence times of the drug in the upper part of the gastrointestinal tract.
Prepared formulations were characterized in their solid state by solubility study; differential scanning calorimetry, scanning electron microscopy, and Fourier transform infrared spectroscopy which demonstrated changes in the formulations supporting the improved solubility. Analysis of dissolution data of optimized formula indicated the best fitting with Peppas-Korsmeyer model and the drug release kinetics was fickian diffusion. Convolvulus pluricaulis Convolvulaceae , Evolvulus alsinoides Convolvulaceae , Clitoria ternatea Papilionaceae , and Canscora decussata Gentianaceae are botanical claimants of Shankhpushpi.
This investigation is to focus the identification of the compound based on biological marker differentiation of four botanical claimants of Shankhpushpi for their antioxidant evaluation on thin layer chromatography TLC by 2,2-diphenylpicrylhydrazyl DPPH method. Antioxidants are attributed for their beneficial role in age-related cognition decline.
The proposed method provides an edge in terms of identification and quantification of antioxidant constituents in a multi-component system.
This method may also provide application for identification of correct plant sources used in the name of Shankhpushpi in marketed ayurvedic formulation, food supplement, and extracts. Formulation and in vitro evaluation of Eudragit S coated naproxen matrix tablets for colon-targeted drug delivery system p.
The tablets were further coated with different concentrations of Eudragit S, a pH-sensitive polymer, by dip immerse method.
In vitro drug release studies of tablets were carried out in different dissolution media, i. The swelling studies of the optimized formulation were carried out.
The physicochemical parameters of all the formulations were found to be in compliance with the pharmacopoeial standards. The effect of dissolution medium on the surface of matrix tablet was determined by using Scanning Electron Microscopy technique. It is estimated that the permeability of the buccal mucosa is times greater than that of the skin. In general, the permeabilities of the oral mucosae decrease in the order of sublingual greater than buccal, and buccal greater than palatal.
At physiological pH the mucus network carries a negative charge due to the sialic acid and sulfate residues which may play a role in mucoadhesion. At this pH mucus can form a strongly cohesive gel structure that will bind to the epithelial cell surface as a gelatinous layer.
Major limitation of the buccal route of administration is the lack of dosage form retention at the site of absorption. Consequently, bioadhesive polymers have extensively been employed in buccal drug delivery systems. Polymers which can adhere to either hard or soft tissue have been used for many years in surgery and dentistry.
Diverse classes of polymers have been investigated for their potential use as mucoadhesives. These include synthetic polymers such as monomeric a cyanoacrylate, polyacrylic acid. An ideal buccal film should be flexible, elastic, and soft yet strong enough to withstand breakage due to stress from activities in the mouth.
So it must possess good mucoadhesive strength so that it is retained in the mouth for the desired duration. To prevent discomfort, swelling of the film should not be too extensive. The mechanical, bioadhesive, and swelling properties of buccal films are critical and must be evaluated.
Various mucoadhesive devices, including tablets, films, patches, disks, strips ,ointments, and gels, have recently been developed. Eudragit providing good drug release barier with good adhesive strength. Gastrointestinal Drug Delivery gastroretentive dosage forms have been designed based on the approaches, Low density form of the dosage form that causes buoyancy in gastric fluid, High density dosage form that is retained in the bottom of the stomach, Bioadhesion to stomach mucosa, Slowed motility of the gastrointestinal tract by concomitant administration of drugs or excipients, Expansion by swelling or unfolding to a large size which limits emptying of the dosage form through the pyloric sphincter.
All these techniques we can achieved with different grades of eudragit. Both of them produce films resistant to gastric fluid. Eudragit L is available as an organic solution Isopropanol , solid or aqueous dispersion.
Eudragit S is available only as an organic solution Isopropanol and solid. Sodium para aminosalicylate Pellets were coated with Eudragit L 30 D using fluidized bed processor and evaluated for in vitro dissolution behavior in 0. Colon Drug Delivery Colonic drug delivery is a recent approach for the treatment of diseases like ulcerative colitis, Crohn's disease, and irritable bowel syndrome.
Tegaserod maleate was used as a drug for irritable bowel syndrome, whereas Eudragit L and S mixture , , and were used. Transdermal Drug Delivery The mechanical properties of casted Eudragit E films were tested for the combined effect of two cohesion promoters succinic or citric acid and triacetin as a plasticizer.